SELECT PGT-A – TAKE ACTION!

Take action!

If you are a patient, thinking of opting for Preimplantation genetic testing (PGT):

  • Talk to your fertility specialist, IVF specialist or gynecologist first as these tests need a referral
  • Connect with our genetic counsellors and understand the benefits of these tests for you and your future children. Be informed and aware of the procedure and seek clarification wherever necessary.
  • Follow up with your fertility specialist, IVF specialist or gynecologist to understand the coverage of these tests and contact us if required.

If you are a Healthcare Provider, seeking a reliable laboratory to conduct Preimplantation genetic testing for your patients to support better IVF outcomes:
Fill in the Contact Us form along with the patient details and we will contact you.

SELECT PGT-A Process

IVF
Embryos created by IVF are grown up to the blastocyst stage (5 or 6 days after fertilization).

BIOPSY
A sample of about 4-6 cells are biopsied from the portion of the embryo destined to form the placenta. The inner cell mass, which will eventually form the baby, is not touched.

SELECT PGT-A
The removed cells are analyzed by our genetic laboratory, using the most reliable next generation sequencing technology, to determine which embryos are chromosomally normal or abnormal.

DETAILED REPORT
SELECT PGT-A analysis report along with genetic counselling is provided to the patient and the HCP. Implications of the test results and the outcomes are discussed along with the impact on the fertility journey.

TRANSFER OF EUPLOID EMBRYOS
Chromosomally healthy embryos are selected for the transfer into the uterus (euploid embryos). This selection increases the chances of pregnancy. The remainder of chromosomally normal embryos are frozen for potential use in a future cycle. This step, supported by the test results, happens in your IVF clinic.

SELECT PGT-A RESULTS
For each embryo tested, the results will fall into one of the following 3 categories:

Euploid
All cells have the correct number of chromosomes. Embryo is suitable for transfer.

Aneuploid
All cells have the incorrect number of chromosomes.
Embryo is not suitable for transfer.

Mosaic
Embryo has a mixture of cells with correct and incorrect number of chromosomes. May be considered for transfer if no other euploid embryos are available.

Limitations of SELECT PGT-A

  • SELECT PGT-A can identify chromosomally normal embryos for uterine transfer; however, this does not guarantee a pregnancy. Other non-genetic factors may be responsible for the same.
  • SELECT PGT-A only tests for chromosome copy number and is unable to identify genetic conditions such as cystic fibrosis. If you know your genetic risk, in that case, SELECT PGT-M or SELECT PGT-SR will be recommended. Discuss this with your Reprobiogen genetic counsellor.
  • Accuracy is ~98%: There is a chance for a false positive or false negative result. Prenatal diagnostic testing (amniocentesis or CVS) during pregnancy is recommended to confirm the results of SELECT PGT-A.
  • SELECT PGT-A tests only embryo biopsies, 4 to 6 cells, not whole embryos. Therefore, mosaicism cannot be ruled out.
  • In some cases, due to issues beyond the reach of Reprobiogen, the sample may get affected due to improper transportation or improper biopsy procedure. In such situations the test cannot be performed on the compromised sample and additional biopsy will be required to obtain results.

FAQ

How long does it take to have SELECT PGT-A Test results?

The Reprobiogen team provides the fastest results for all genetic testing. SELECT PGT-A results may be available in as little as 5-8 business days.

Can SELECT PGT-SR and SELECT PGT-A be done at the same time?

Yes. The same genetic material can be used to screen both the chromosomal health of the embryo (SELECT PGT-A) and to determine chromosomal rearrangements (SELECT PGT-SR).