PGT for Structural Rearrangements (SELECT PGT-SR)

What is

SELECT PGT-SR is a specialized test for couples where one of the partners carries a known balanced structural rearrangement in their chromosomes.

Preimplantation genetic testing for structural rearrangements also known as SELECT PGT-SR checks for the presence of unbalanced chromosomal rearrangements on the embryos produced by the IVF process. The test detects abnormalities and reports if any chromosomal rearrangements (segmental gains/losses) are present that can increase the risk of producing embryos with incorrect genetic material causing adverse fertility outcomes, miscarriages, and abnormalities in the offspring.

This test is a proactive step and can assist in improving the IVF results and achieve a healthy pregnancy. SELECT PGT-SR is hence considered as Comprehensive Chromosome Screening (CCS). During this test embryos created during the In-vitro Fertilization (IVF) process are screened and only the healthy embryos with the right chromosomal arrangement are set aside for embryo implantation in the uterus.


  • Identifies embryos affected with a genetic disorder before transfer. This selection increases the
    chances of pregnancy and having a baby with no genetic defect/abnormality.
  • It has a 98% accuracy rate in detecting chromosomal abnormalities in embryos.
  • Genetic counseling sessions to assist informed decisions.

Who should opt for SELECT PGT-SR?

SELECT PGT-SR is useful for individuals who have a chromosomal rearrangement. You may consider SELECT PGT-SR if you have had a child with a structural rearrangement, or if you or your partner are carriers of any of the following types of chromosomal rearrangements:

  • Reciprocal translocation: Pieces of chromosomes have switched places.
  • Robertsonian translocation: Chromosomes link together and create an abnormal chromosome count. This can cause conditions including trisomy 13 and uniparental disomy (UPD). This type of rearrangement may also result in translocation Down syndrome.
  • Unbalanced translocation: Where the exchange of chromosome material is unequal resulting in extra or missing genes
  • Deletion/duplication: piece of chromosome that is either deleted or duplicated
  • Inversion: Part of a chromosome is turned upside down and reinserted back into the chromosome.